The use of Analgin helps with pain syndromes of different origin: 

• headache and migraine pain, 

• neuralgia, 

• myalgia,

• toothache,

• oligomenorrhea, 

• chorea, 

• rheumatism, 

• radiculitis, 

• fever caused by infectious and inflammatory diseases.

        Also, the drug is used in surgical practice to eliminate postoperative pain. For renal and biliary colic, the use of Analgin is effective in combination with antispasmodic drugs.

        It is a derivative of pyrazolone. It is characterized by a pronounced analgesic, antipyretic and minor anti-inflammatory action.

        Anti-inflammatory effect of metamizole is also caused by inhibition of prostaglandin production.

        The antipyretic effect of Analgin is ensured by the ability to reduce production and release of chemical substances that affect heat production.

        Analgesic action is provided by the ability of the active substance to inhibit cyclooxygenase and the synthesis of prostaglandins (they take part in the development of inflammatory and pain reactions). In addition, Metamizole blocks the transmission of pain impulses and increases the threshold of sensitivity of pain centres, reduces the response of brain structures to pain caused by a particular irritant.

Analgin also has an antispasmodic effect on the smooth muscles of the biliary and urinary tract.

        According to the instructions for use prescribed analgin inside, intramuscularly or intravenously. The dosage depends on the intensity of pain, fever and individual reaction in response to taking Analgin. The smallest effective dose controlling pain and fever should be chosen. Tablets should be swallowed whole, with a sufficient amount of liquid (for example, a glass of water).

        Inside taken after meals. Dose for adults - 0.25-0.5 g 2-3 times a day; with rheumatism - up to 1 g 3 times a day. Children inside - 5-10 mg / kg 3-4 times a day.

        Intramuscularly or intravenously (with severe pain) is administered to adults in 1-2 ml of 50% or 25% solution 2-3 times a day; no more than 2 g per day. Children are administered at the rate of 0.1-0.2 ml of a 50% solution or 0.2-0.4 ml of a 25% solution per 10 kg of body weight.

Higher doses for adults inside: single - 1 g, daily - 3 g; intramuscularly and into a vein: single - 1 g, daily - 2 g. High doses should be avoided with reduced renal or hepatic function. Perhaps short-term use without dose reduction. Prolonged use is not possible. Long-term treatment requires regular blood monitoring, including the counting of white blood cells.

The annotation lists the following contraindications to the use of Analgin:

• hypersensitivity to metamizole sodium, to other components of the drug and/or pyrazolone derivatives (propafenone, aminophenazone, phenazone);

• hematopoietic oppression (agranulocytosis, neutropenia, leukopenia);

• anaemia, including hereditary hemolytic anaemia associated with a deficiency of glucose-6-phosphate dehydrogenase;

• asthma caused by acetylsalicylic acid;

• renal and/or liver failure;

• pregnancy;

• breastfeeding period;

• age up to 15 years.

        In pediatric practice, tablets are used from the age of ten, suppositories in children older than one year. Intramuscular medication should not be administered to children up to three months, as well as children weighing up to five kilograms. Contraindications for intravenous administration of Analgin are children from three to eleven months.

Side effects when using Analgin can manifest as:

• On the part of the urinary system: renal dysfunction, oliguria, anuria, proteinuria, interstitial nephritis, urine staining in red.

• From the side of blood-forming organs: agranulocytosis, leukopenia, thrombocytopenia.

• Allergic reactions: urticaria (including on the conjunctiva and the mucous membranes of the nasopharynx), angioedema, in rare cases - malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), bronchospastic syndrome, anaphylactic shock.

• Other: decrease in blood pressure. Local reactions: with intramuscular injection, infiltrates are possible at the injection site.